In their first game since the resignation of manager Nigel Lee, the O's took the lead against their Premier Division opponents on twelve minutes, Ben Harris setting up Liam Jenkins.
By the half hour mark though, they were behind after Sherborne scored two quick goals and the home side added two more late in the game to give the result an unfairly one-sided look about it.
To add injury to insult (literally), Ali Bamford went off just after the hour mark with suspected ligament damage but this was later found to be a broken fibula.
Team: Perry, Bamford, Sarre, J Comley, Clail, Planter, Hutton, Side, P Comley, Harris, Jenkins.
Subs: Holbrook, Gregory.